Protagonists
- Zhang Wuji (张无忌 – Zhāng Wújì) – Protagonist, Ming Order leader
- Zhao Min (赵敏 – Zhào Mǐn) – Daughter of Yuan general
- Zhou Zhiruo (周芷若 – Zhōu Zhĭruò) – Emei Order leader
Wudang Order
Seven Heroes of Wudang
- Song Yuanqiao (宋远桥 – Sòng Yuǎnqiáo) – Most senior disciple
- Yu Lianzhou (俞莲舟 – Yú Liánzhōu) – Most skilled disciple, later becomes leader
- Yu Daiyan (俞岱岩 – Yú Dàiyán) – Paralyzed by Asan
- Zhang Songxi (张松溪 – Zhāng Sōngxī) – Most intelligent of the seven
- Zhang Cuishan (张翠山 – Zhāng Cuìshān) the Silver Hook Iron Brush – Zhang Wuji’s father
- Yin Liting (殷梨亭 – Yīn Lítíng) – Ji Xiaofu’s former fiancé
- Mo Shenggu (莫声谷 – Mò Shēnggǔ) – Youngest and most hot-tempered
Other members
- Zhang Sanfeng (张三丰 – Zhāng Sānfēng), formerly Zhang Junbao (张君宝 – Zhāng Jūnbǎo) – Founder and leader
- Song Qingshu (宋青书 – Sòng Qīngshū) the Jade-Faced Mengchang – Song Yuanqiao’s son
Emei Order
- Guo Xiang (郭襄 – Guō Xiāng) – Founder, daughter of Guo Jing and Huang Rong
- Miejue (灭绝师太 – Mièjué Shītài) – Current leader
- Guhongzi (孤鸿子 – Gūhóngzǐ) – Miejue’s deceased senior
- Ji Xiaofu (纪晓芙 – Jǐ Xiǎofú) – Former potential successor
- Ding Minjun (丁敏君 – Dīng Mǐnjūn) – Senior disciple
- Bei Jinyi (贝锦仪 – Bèi Jǐnyí) – Junior disciple
Other disciples
- Zhao Lingzhu (赵灵珠 – Zhào Língzhū)
- Li Mingxia (李明霞 – Lǐ Míngxiá)
- Su Mengqing (苏梦清 – Sū Mèngqīng)
- Fang Bilin (方碧琳 – Fāng Bìlín)
Jing disciples
- Jingxuan (静玄 – Jìngxuán)
- Jinghui (静慧 – Jìnghuì)
- Jingxu (静虚 – Jìngxū)
- Jingzhao (静照 – Jìngzhào)
- Jingjia (静迦 – Jìngjiā)
- Jingkong (静空 – Jìngkōng)
- Jingxian (静闲 – Jìngxián)
- Jingzhen (静真 – Jìngzhēn)
- Jingdao (静道 – Jìngdào)
- Jingfeng (静风 – Jìngfēng)
- Jingxin (静心 – Jìngxīn)
- Jinghe (静和 – Jìnghé)
Ming Order
- Yang Xiao (杨逍 – Yáng Xiāo) the Bright Left Messenger – Former acting cult leader and Zhang Wuji’s adviser
- Fan Yao (范遥 – Fàn Yáo) the Bright Right Messenger, also known as Kutoutuo (苦头陀 – Kǔtoutuó) – Ming Order spy
Four Guardian Kings
- Daiqisi (黛绮丝 – Dàiqǐsī) the Purple Dress Dragon King – Persian Ming Order Sacred Maiden
- Yin Tianzheng (殷天正 – Yīn Tiānzhèng) the White Brows Eagle King – Founder of Heavenly Eagle Cult
- Xie Xun (谢逊 – Xiè Xùn) the Golden Haired Lion King – Zhang Wuji’s godfather
- Wei Yixiao (韦一笑 – Wéi Yīxiào) the Green Winged Bat King – Known for qinggong prowess
Other Ming Order members
- Yang Buhui (杨不悔 – Yáng Bùhuǐ) – Daughter of Yang Xiao and Ji Xiaofu
- Zhu Yuanzhang (朱元璋 – Zhū Yuánzhāng) – Ambitious cult member who later founds Ming dynasty
- Chang Yuchun (常遇春 – Cháng Yùchūn) – Member saved by Zhang Wuji
- Xu Da (徐达 – Xú Dá) – Military tactician who studies Book of Wumu
Five Wanderers
- Leng Qian (冷谦 – Lěng Qiān) the Cold Faced Gentleman
- Shuobude (说不得 – Shuōbùdé) the Monk with the Sack
- Zhang Zhong (张中 – Zhāng Zhōng) the Iron Crowned Taoist
- Peng Yingyu (彭莹玉 – Péng Yíngyù) the Peng the Monk
- Zhou Dian (周颠 – Zhōu Diān) the Lunatic
Other Ming Order figures
- Hu Qingniu (胡青牛 – Hú Qīngniú) – Physician known for selective treatment
- Wang Nangu (王难姑 – Wáng Nàngū) – Hu Qingniu’s wife and toxicology expert
- Yang Dingtian (阳顶天 – Yáng Dǐngtiān) – Former Ming Order leader
Chiefs of the Five Elements factions
- Zhuang Zheng (庄铮 – Zhuāng Zhēng) – Gold Banner Faction chief
- Wu Jingcao (吴劲草 – Wú Jìngcǎo) – New Gold Banner Faction chief
- Yan Yuan (颜垣 – Yán Yuán) – Earth Banner Faction chief
- Tang Yang (唐洋 – Táng Yáng) – Water Banner Faction chief
- Wen Cangsong (闻苍松 – Wén Cāngsōng) – Wood Banner Faction chief
- Xin Ran (辛然 – Xīn Rán) – Fire Banner Faction chief
Heavenly Eagle Order
- Yin Susu (殷素素 – Yīn Sùsù) – Zhang Wuji’s mother
- Yin Yewang (殷野王 – Yīn Yěwáng) – Yin Susu’s brother
- Yin Li (殷离 – Yīn Lí), also known as Zhu’er (蛛儿 – Zhū’ér) – Yin Yewang’s daughter
Leaders of halls and altars
- Li Tianyuan (李天垣 – Lǐ Tiānyuán) – Heaven Hall leader
- Chang Jinpeng (常金鹏 – Cháng Jīnpéng) – Vermilion Bird Altar leader
- Bai Guishou (白龟寿 – Bái Guīshòu) – Black Tortoise Altar leader
- Cheng Chaofeng (程嘲风 – Chéng Cháofēng) – Azure Dragon Altar leader
- Gao Shanwang (高山王 – Gāo Shānwáng) – White Tiger Altar leader
- Feng Gongying (封弓影 – Fēng Gōngyǐng) – Divine Snake Altar leader
Other members
- Yin Wufu (殷无福 – Yīn Wúfú) – Southwest bandit
- Yin Wulu (殷无禄 – Yīn Wúlù) – Southwest bandit
- Yin Wushou (殷无寿 – Yīn Wúshòu) – Southwest bandit
Persian Ming Order
- Xiaozhao (小昭 – Xiǎozhāo) – Han Qianye and Daiqisi’s daughter
Messengers
- Mysterious Wind Messenger (妙风使 – Miàofēng Shǐ)
- Drifting Cloud Messenger (流云使 – Liúyún Shǐ)
- Bright Moon Messenger (辉月使 – Huīyuè Shǐ)
Guardian Kings
- Equality Guardian King (平等宝树王 – Píngděng Bǎoshùwáng)
- Unity Guardian King (齐心宝树王 – Qíxīn Bǎoshùwáng)
- Transparent Guardian King (俱明宝树王 – Jùmíng Bǎoshùwáng)
- Victorious Guardian King (常胜宝树王 – Chángshèng Bǎoshùwáng)
Yuan Empire
- Chaghan Temür (察罕特穆儿 – Cháhǎn Tèmù’ér) the Prince of Ruyang – Zhao Min’s father
- Lady Han (韩氏女 – Hán Shìnǚ) – Chaghan Temür’s concubine
- Köke Temür (扩廓帖木儿 – Kuòkuò Tiēmù’ér), also known as Wang Baobao (王保保 – Wáng Báobǎo) – Zhao Min’s brother
- Lu Zhangke (鹿杖客 – Lù Zhàngkè) – Xuanming Elder
- He Biweng (鹤笔翁 – Hè Bǐwēng) – Xuanming Elder
Divine Arrow Eight Heroes
- Zhao Yishang (赵一伤 – Zhào Yīshāng)
- Qian Erbai (钱二败 – Qián Èrbài)
- Sun Sanhui (孙三毁 – Sūn Sānhuǐ)
- Li Sicui (李四摧 – Lǐ Sìcuī)
- Zhou Wushu (周五输 – Zhōu Wǔshū)
- Wu Liupo (吴六破 – Wú Liùpò)
- Zheng Qimie (郑七灭 – Zhèng Qīmiè)
- Wang Bashuai (王八衰 – Wáng Bāshuāi)
Shaolin Order
- Jueyuan (觉远 – Juéyuǎn) – Zhang Junbao’s master
- Cheng Kun (成昆 – Chéng Kūn) the Primordial Chaos Thunderbolt Hand, also known as Yuanzhen (圆真 – Yuánzhēn) – Main antagonist
Four Holy Monks
- Kongjian (空见 – Kōngjiàn) – Master of invincibility
- Kongwen (空闻 – Kōngwén) – Shaolin abbot
- Kongzhi (空智 – Kōngzhì) – Hot-tempered senior monk
- Kongxing (空性 – Kōngxìng) – Murdered by Asan
Three Elders of Bodhidharma Hall
- Du’e (渡厄 – Dù’è) – One-eyed elder
- Dujie (渡劫 – Dùjié)
- Dunan (渡难 – Dùnàn)
Other schools
Kunlun School
- He Zudao (何足道 – Hé Zúdào) the Kunlun Three Sage – Senior member
- He Taichong (何太冲 – Hé Tàichōng) the Iron Qin Gentleman – School leader
- Ban Shuxian (班淑娴 – Bān Shūxián) – He Taichong’s wife
Huashan School
- Xianyu Tong (鲜于通 – Xiānyú Tōng) the Shenjizi – School leader
- Xue Gongyuan (薛公远 – Xuē Gōngyuǎn) – Xianyu Tong’s apprentice
Kongtong School
- Guan Neng (关能 – Guān Néng) – Elder
- Zong Weixia (宗维侠 – Zōng Wéixiá) – Elder
- Tang Wenliang (唐文亮 – Táng Wénliàng) – Elder
- Chang Jingzhi (常敬之 – Cháng Jìngzhī) – Elder
- Jian Jie (简捷 – Jiǎn Jié) – Minor member
Beggars’ Guild
- Chen Youliang (陈友谅 – Chén Yǒuliàng) – Cheng Kun’s apprentice
- Shi Huolong (史火龙 – Shǐ Huǒlóng) – Former Guild chief
- Shi Hongshi (史红石 – Shǐ Hóngshí) – Shi Huolong’s daughter and successor
Other characters
- Han Qianye (韩千叶 – Hán Qiānyè) the Silver Leaf Gentleman – Xiaozhao’s father
- The Yellow Dress Maiden (黄衫女子 – Huángshān Nǚzǐ) – Mysterious helper
- Situ Qianzhong (司徒千钟 – Sītú Qiānzhōng) – Martial artist
- Xia Zhou (夏胄 – Xià Zhòu) – Victim’s brother
- Du Baidang (杜百当 – Dù Bǎidāng) – Victim’s father
- Yi Sanniang (易三娘 – Yì Sānniáng) – Victim’s mother